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April 13, 2021

Bispecific Estrogen Receptor α Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening

April 12th 2021|J.Med.Chem 2021|Bispecific Estrogen Receptor α Degraders Incorporating Novel Binders Identified Using DNA-Encoded Chemical Library Screening Bispecific degraders (PROTACs) of ERα are expected to be advantageous over current inhibitors of ERα signaling (aromatase inhibitors/SERMs/SERDs) used to treat ER+ breast cancer. Information from DNA-encoded chemical library (DECL) screening provides a method to identify novel PROTAC […]

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April 1, 2021

Arbutus Biopharma, X-Chem and Proteros biostructures Enter into a Pan-Coronavirus Discovery Research and License Agreement

Collaboration formed to accelerate the discovery of novel oral inhibitors targeting the SARS-CoV-2 nsp5 main protease for the treatment of COVID-19 and potential future coronavirus outbreaks WARMINSTER, PA, WALTHAM, MA, MUNICH, GERMANY, April 1, 2021 — Arbutus Biopharma Corporation (NASDAQ: ABUS), X-Chem, Inc. (X-Chem) and Proteros biostructures GmbH (Proteros) announced today that they have entered […]

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February 2, 2021

X-Chem Enters into Multitarget Oncology Discovery Research Collaboration and License Agreement with Genentech

 Collaboration Includes Licensing of Preclinical Small Molecule Program  WALTHAM, Mass.; Feb. 2, 2021 (Business Wire) – X-Chem, Inc., a global leader in DNA-Encoded Library (DEL) technology to identify novel drug leads, announced today that it has entered into a research collaboration and license agreement with Genentech, a member of the Roche Group. The goal of […]

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