Science and Technology
December 5, 2014

Publications

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Publications

February 24, 2014

Bigger is Better

February 24, 2014 | BioCentury | “Bigger is Better”

“The vision is that when the library is big enough, molecules that are practically drug candidates will emerge from the primary screen.”

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February 13, 2014

Overview of Recent Progress in Protein-Expression Technologies for Small-Molecule Screening

February 13, 2014 | Journal of Biomolecular Screening | “Overview of Recent Progress in Protein-Expression Technologies for Small-Molecule Screening”

Production of novel soluble and membrane-localized protein targets for functional and affinity-based screening has often been limited by the inability of traditional protein-expression systems to generate recombinant proteins that have properties similar to those of their endogenous counterparts.

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January 31, 2014

Universal strategies for the DNA-encoding of libraries of small molecules using the chemical ligation of oligonucleotide tags

January 31, 2014 | Taylor Francis Online | “Universal strategies for the DNA-encoding of libraries of small molecules using the chemical ligation of oligonucleotide tags”

The affinity-mediated selection of large libraries of DNA-encoded small molecules is increasingly being used to initiate drug discovery programs.

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