Success Stories of DEL Enablement

November 15, 2023

X-Chem’s primary mission has always been to leverage the world’s leading drug discovery platform to help create molecules that will...


Proximity Labeling: DEL Selection Without Capturing the Target

October 18, 2023

DNA-encoded library (DEL) selections typically use affinity pulldown to enrich compounds that bind targets of interest. While it is highly...


The Power of DNA-Encoded Libraries for Covalent Inhibitor Discovery

September 13, 2023

Most of the pharmaceutical industry’s reported drug discovery projects involve reversible target modulators. However, covalent inhibitors — i.e., irreversible —...


DEL Screen Artifacts: How to Find and Avoid Them

August 16, 2023

As experts in the DNA-encoded chemical library (DEL) field with over twelve years of experience in screening DELs, X-Chem has...


DEL Technology and Targeted Protein Degradation Discovery

July 19, 2023

Targeted protein degradation (TPD) is a rapidly growing field that aims to selectively eliminate disease-causing proteins.1,2 Proteolysis targeting chimeras (PTCs)...


Protein-Protein Interactions: A Key to Precision Medicine

June 21, 2023

Protein-protein interactions (PPIs) are the foundation of life, controlling everything from cell growth and division to metabolism and signaling.1 Targeting...


Going Beyond Hit ID With Machine Learning & Del: The Prediction of Building Block Reactivity

June 7, 2023

Since X-Chem and Google’s seminal collaboration applying machine learning (ML) to DNA-encoded chemical library (DEL) screening output, ML has taken...


Through the Lens of a Lead Discovery Scientist: Enabling Hit Identification Through DNA-Encoded Libraries

February 15, 2023

The phrase “you miss 100% of the shots you don’t take” was originally coined by Wayne Gretzky about scoring goals...


A Year of Driving Small Molecule Discovery

January 3, 2023

2022 was a big year here at X-Chem, so as we embark into 2023 it seems like a good time...