September 9, 2021

Research Scientist (Montreal, Canada)


X-Chem, Inc. is the leader in small molecule discovery science, providing pharmaceutical and biotech companies a complete, seamless solution for screening, hit validation and lead optimization. As pioneers of DNA-encoded chemical library (DEL) technology, the company leverages its market-leading DEL platform to discover novel small molecule leads against challenging, high-value therapeutic targets. X-Chem empowers partners to rapidly screen billions of diverse, drug-like compounds simultaneously and easily identify potent hits that exhibit desired selectivity and mode of action with attractive physicochemical properties. In-house lead optimization services enable clients to progress their compounds directly for even higher quality outputs. Our expertise in medicinal chemistry, custom synthesis and scale-up process chemistry enables us to support all aspects of drug discovery, supporting lead optimization through candidate identification.

X-Chem is seeking a candidate for the position of Research Scientist.  The Research Scientist will work independently within a project team structure, design and execute synthetic routes and troubleshoot when needed.

Key Responsibilities:

  • Perform design and synthesis of novel target molecules as part of a project team
  • Plan effective, well-designed routes and reaction design on challenging targets
  • Solve reaction issues using extensive mechanistic and physical organic understanding
  • Carry-out troubleshooting and optimize reaction sequences
  • Complete ELN and project documents on time with no technical or scientific errors
  • Prepares reports and patents drafts
  • Participate in project team meetings
  • Act as a mentor to junior colleagues
  • Prepare summary documents and presentations to chemistry, project teams

Skills and Qualifications

  • Requirements for this position include a Ph.D. in organic, bioorganic, or medicinal chemistry or a related field, with 0-5 years of post-doctoral experience
  • Comprehensive and up-to-date knowledge of synthetic organic chemistry
  • Thorough mechanistic understanding and demonstrated expertise in more complex heterocyclic and organometallic synthesis, total synthesis, transitional metal catalysis, etc.
  • Demonstrated laboratory proficiency
  • Experience with the operation of standard laboratory instrumentation (e.g. NMR, MS, automated chromatography), and data analysis
  • Able to work within a team structure and effectively communicate with colleagues at all levels
  • Strong research track record as evidenced by a strong publication and/or patent record
  • Entrepreneurial spirit, and constantly seeking creative solutions to challenging problems
  • Excellent oral and written communication skills

Why you should join us:

X-Chem offers competitive compensation and benefits package in order to support our people.  Benefits we offer include:  medical, dental, short- and long-term disability, life insurance, and a retirement plan with employer match, 3 weeks paid vacation and paid end of year shutdown, social hours and company events.

Job Code INT2101
Contact Name Human Resources
Position Location:  Montreal, Canada

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