Découverte d'inhibiteurs bactéricides de Mycobacterium tuberculosis InhA, spécifiques du cofacteur, à l'aide de la technologie des bibliothèques codées en ADN.
Millions of individuals are infected with and die from tuberculosis (TB) each year, and multidrug-resistant (MDR) strains of TB are increasingly prevalent…We describe here the use of DNA-encoded X-Chem (DEX) screening, combined with selection of appropriate physical properties, to identify multiple classes of InhA inhibitors with cell-based activity…
