Case Study Archives - X-Chem https://www.x-chemrx.com/portfolio_category/case-study/ Take the Lead. Drive Discovery. Wed, 28 Jan 2026 16:43:51 +0000 en-US hourly 1 https://wordpress.org/?v=6.9.4 X-Chem’s Search for BRD4 Inhibitors Shows Our Ability to Drive New Discovery https://www.x-chemrx.com/projects/x-chems-search-for-brd4-inhibitors-shows-our-ability-to-drive-new-discovery/ https://www.x-chemrx.com/projects/x-chems-search-for-brd4-inhibitors-shows-our-ability-to-drive-new-discovery/#respond Wed, 22 Sep 2021 14:40:09 +0000 https://ggdev9.com/?post_type=avada_portfolio&p=3692 X-Chem is well-known for our pioneering work in DNA-encoded libraries (DELs), but we also offer end-to-end drug discovery solutions. Read how X-Chem has successfully applied its medicinal chemistry and protein science expertise to identify, characterize and optimize a new set of inhibitors for the difficult-to-drug target, BRD4. In this case study we: Identify opportunity [...]

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X-Chem is well-known for our pioneering work in DNA-encoded libraries (DELs), but we also offer end-to-end drug discovery solutions.

Read how X-Chem has successfully applied its medicinal chemistry and protein science expertise to identify, characterize and optimize a new set of inhibitors for the difficult-to-drug target, BRD4.

In this case study we:

  • Identify opportunity in BRD4 inhibitors
  • Perform competitive analysis of leading candidates and competitors
  • Identify superior characteristics to competitors
  • Computationally assess structure and function relationships that will lead to superior characteristics
  • Experimentally find and validate drug candidates with desired features via X-ray crystallography
  • Perform IND-enabling studies (ongoing)

Learn more about X-Chem’s drug discovery process of BRD4 inhibitors by reading the full case study.

The post X-Chem’s Search for BRD4 Inhibitors Shows Our Ability to Drive New Discovery appeared first on X-Chem.

]]> https://www.x-chemrx.com/projects/x-chems-search-for-brd4-inhibitors-shows-our-ability-to-drive-new-discovery/feed/ 0 Discovering Autotaxin Inhibitors Using DNA-Encoded Libraries for the Treatment of Idiopathic Pulmonary Fibrosis https://www.x-chemrx.com/projects/discovering-autotaxin-inhibitors-using-dna-encoded-libraries-for-the-treatment-of-idiopathic-pulmonary-fibrosis/ https://www.x-chemrx.com/projects/discovering-autotaxin-inhibitors-using-dna-encoded-libraries-for-the-treatment-of-idiopathic-pulmonary-fibrosis/#respond Fri, 10 Sep 2021 14:44:40 +0000 https://ggdev9.com/?post_type=avada_portfolio&p=3695 Read how X-Chem successfully searched for compounds capable of inhibiting the novel autotaxin, an enzyme involved in inflammatory signaling and implicated in a wide range of human disease. To find a drug for this high-value target, X-Chem used their proprietary DNA-encoded chemical library platform to screen for autotaxin inhibitors. In this case study we [...]

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Read how X-Chem successfully searched for compounds capable of inhibiting the novel autotaxin, an enzyme involved in inflammatory signaling and implicated in a wide range of human disease. To find a drug for this high-value target, X-Chem used their proprietary DNA-encoded chemical library platform to screen for autotaxin inhibitors.

In this case study we highlight:

  • Discovery of X-165, a highly potent, selective inhibitor of autotaxin by using DEL technology
  • Characterization of the unique binding modality that differentiates X-165 molecule from any previous autotaxin inhibitor candidate
  • Completion of IND-enabling studies, leading the U.S. FDA to approve X-165 for Phase I clinical trials

Learn more about X-Chem’s drug discovery process of X-165 by reading the full case study.

The post Discovering Autotaxin Inhibitors Using DNA-Encoded Libraries for the Treatment of Idiopathic Pulmonary Fibrosis appeared first on X-Chem.

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