Molecular glues have historically been discovered serendipitously, while bifunctional strategies have enabled more rational approaches to proximity-based modulation. DNA-encoded [...]
DNA-encoded library (DEL) screening generates -omics scale ligand-target interaction datasets within a single experiment, shifting the bottleneck for drug discovery [...]
An X-Chem DEL-derived compound enabled this work that explores a novel mechanistic strategy for HIV therapeutics. DCAF1 is a donut-shaped WD40 [...]
DNA-encoded library (DEL) screening enables identification of small-molecule binders from libraries containing billions of compounds, yet much of the [...]
Eukaryotic initiation factor 2B (eIF2B), a guanine nucleotide exchange factor (GEF), promotes protein synthesis by charging translation initiation factor [...]
There is considerable interest in the discovery of novel molecular glues that induce proximity between oncology targets and their [...]
Aberrant expression of the transcription factor Brachyury (also known as TBXT) drives the growth of chordoma, a rare bone [...]
DNA-encoded chemical library (DEL) technology has become a powerful tool for hit identification, enabling the efficient screening of large [...]
DNA-encoded library (DEL) screening with encoded combinatorial chemical synthesis has emerged as a powerful approach to discover novel ligands [...]
Herein, we report a general and scalable continuous flow metallaphotoredox amidine arylation protocol that efficiently couples diverse (hetero)aryl halides [...]
Posters and PublicationsAdminGG2025-09-23T12:37:01-04:00
