Patents | November 11, 2017

AstraZeneca AB, Swed. .; Preparation of substituted imidazole and triazole compounds as inhibitors of protease-activated receptor-2

The present application relates to certain substituted imidazole and triazole compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating pain, musculoskeletal inflammation, neuroinflammatory disorders, airway inflammation, itch, dermatitis, colitis and related conditions. The compounds are of Formula (I) where X is N or CH, Z and Y are N or C (but both not N) and R1-R3 are as defined herein.

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