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Learn more through X-Chem resources such as brochures, case studies, articles and webinars.
DNA-encoded library (DEL) screening has historically been used to identify [...]
Macrocyclic DNA-encoded libraries (DELs) offer a powerful approach for [...]
Covalent drug discovery has reshaped pharma, expanding targetable residues [...]
Mirror-image DEL Screen: Best-in-class Hit Discovery Solutions RNA-targeting [...]
Rebecca Swett, Director of Computational Chemistry at X-Chem, joins Host [...]
DNA-encoded chemical library (DEL) technology enables the efficient screening [...]
Training machine-learned models using DNA-Encoded Chemical Library screening data [...]
Discovering RNA-binding small molecules is a formidable challenge with [...]
Described herein are compounds and compositions useful for preventing [...]
Cyclopropanes play an important role in drug discovery, and [...]
The present disclosure provides methods of screening DNA-encoded chemical [...]
Evaluating synthetic accessibility of in silico molecules is an integral component [...]
The recent global COVID-19 pandemic has highlighted treatments for [...]
Machine Learning (ML) can only be powerful if the [...]
Target class-focused drug discovery has a strong track record [...]
Karen Lackey, CEO of X-Chem, has been at the [...]
X-Chem’s DNA-encoded libraries (DELs) contain hundreds of billions of [...]
A Laser-focused Covalent Targeting Strategy With recent FDA [...]
DNA-encoded chemical library (DEL) technology is a fast, reliable, [...]
DNA-encoded chemical library (DEL) technology enables the efficient screening [...]
Amino acids are vital motifs in the domain of [...]
Scientists from X-Chem, in collaboration with researchers at AstraZeneca, [...]
Here we report the use of DNA encoded Library [...]
Bfl-1 is over-expressed in both hematological and solid tumors, [...]
Deuterium-labeled compounds play a pivotal role in physical organic [...]
For numerous rare diseases, the steep costs associated with [...]
The introduction of alkylamines onto heteroaromatics is integral to [...]
X-Chem’s “DELability” offering is recognized as an exceptional innovation [...]
Isotopically labeled compounds play a crucial role in material [...]
DNA-encoded chemical library (DEL) technology provides a time- and [...]
The present invention provides compounds of formula (I): Formula [...]
Dysregulation of IL17A drives numerous inflammatory and autoimmune disorders [...]
The identification of novel covalent ligands for therapeutic purposes [...]
DNA-encoded chemical library (DEL) technology enables the efficient screening [...]
X-Chem’s DNA-Encoded Chemical Library (DEL) platform generates a large [...]
In this webinar, Dr. Anthony Keefe and Dr. Johan [...]
Evasion of apoptosis is critical for the development and [...]
Discover an informative webinar diving into DNA-encoded library (DEL) [...]
The DNA-encoded library (DEL) discovery platform has emerged as [...]
Machine learning has significant promise, but we should never [...]
The integration of artificial intelligence technologies into pharmaceutical research [...]
WD40 repeat-containing protein 91 (WDR91) regulates early-to-late endosome conversion [...]
In this webinar, X-Chem will explore how the synergy between [...]
In this webinar, Philip Carpino, Ph.D., will discuss the [...]
X-Chem has an unrivaled track record of excellence, with [...]
DCAF1 is a substrate receptor of two distinct E3 [...]
DNA-encoded small molecule libraries (DELs) created using combinatorial chemistry [...]
The c-MET receptor tyrosine kinase has received considerable attention [...]
Artificial intelligence (AI) holds the promise of transforming drug [...]
The highest-quality DNA-encoded libraries, available and ready to be [...]
Over the past decade, DNA-encoded libraries (DELs) have emerged [...]
This study describes a novel series of UDP-N-acetylglucosamine acyltransferase [...]
X-Chem is well-known for our pioneering work in DNA-encoded [...]
Read how X-Chem successfully searched for compounds capable of [...]
In this webinar, X-Chem will explore how the synergy [...]
Realize the Full Potential of Your Chemistry Resources With [...]
As a new technology, few labs, companies, or organizations [...]
DNA-Encoded Libraries and Protein Degradation: A Winning Combination for [...]
Crystalline and liquid crystalline forms of 25HC3S sodium are [...]
Libraries of DNA-Encoded small molecules created using combinatorial chemistry [...]
Inhibition of hydroxy acid oxidase 1 (HAO1) is a [...]
An approach of building block (BB) inclusivity and atom [...]
DEL-Driven Drug Discovery With Proven Success for Tough Targets [...]
Focused on Developability From Day One No other [...]
Accelerate Small Molecule Discovery with Unmatched Efficiency Designed [...]
Exclusive Discovery Partnership Tailored to Your Success DELcore [...]
Publication: J.Med.Chem 2021 Bispecific degraders (PROTACs) of ERα are expected [...]
J. Med. Chem. 2021 Mer is a member of [...]
Publication: Nature The structural mechanisms of single-pass transmembrane enzymes remain [...]
Publication: Nature Protease-activated receptor-2 (PAR2) has been implicated in multiple [...]
The present application discloses heteroaromatic and heterobicyclic aromatic derivative [...]
The present disclosure is directed to nitrogen-containing heteroaryl analogs, [...]
The activity of the secreted phosphodiesterase autotaxin produces the [...]
DNA-encoded small molecule libraries (DELs) have enabled discovery of [...]
The invention relates to modulators of Embryonic Ectoderm Development [...]
The present disclosure relates to novel methods for preparing [...]
The present application relates to compounds of formula (I’) [...]
Novel Nucleic Acid Binding Small Molecules Discovered Using DNA-Encoded [...]
The present invention relates to compounds that act as [...]
A practical and asymmetric synthesis of a small-molecule CXCR7 [...]
The present application relates to certain substituted imidazole and [...]
Isoform-Selective ATAD2 Chemical Probe with Novel Chemical Structure and [...]
This application relates to substituted imidazopyridines, compositions comprising them [...]
Structural insight into allosteric modulation of protease-activated receptor 2 [...]
New strategies to potentially improve drug safety and efficacy [...]
This application relates to aryl-substituted dihydroquinolinones of formula (I), [...]
This application relates to N-substituted bicyclic lactams of formula [...]
This application relates to substituted benzimidazoles of formula (I), [...]
January 9, 2018 | Sage Journals | Agonists and [...]
Discovery of a potent BTK inhibitor with a novel [...]
Mcl-1 is a pro-apoptotic BH3 protein family member similar [...]
Publication: Nat Rev Drug Discov. DNA-encoded chemical library technologies are [...]
Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using [...]
A hexanucleotide repeat expansion residing within the C9ORF72 gene [...]
New and emerging directions in pharmaceutical research to better [...]
Encoded Library Synthesis Using Chemical Ligation and the Discovery [...]
Chemical ligation methods for the tagging of DNA-encoded chemical [...]
The present invention relates to compounds useful as bromodomain [...]
Discovering Small Molecule Compounds through The DNA Encoded Library [...]
“The vision is that when the library is big [...]
Overview of Recent Progress in Protein-Expression Technologies for Small-Molecule [...]
The Transient Receptor Potential A1 (TRPA1) ion channel has [...]
Universal strategies for the DNA-encoding of libraries of small [...]
During inflammation, several Transient Receptor Potential (TRP) channels are [...]
This issue of Current Topics in Medicinal Chemistry focuses [...]
Fragment-based lead generation (FBLG) has recently emerged as an [...]
