Validate Your Target. Advance with Confidence.
HitBuilder is your low-commitment entry into discovery with X-Chem. Whether you’re exploring a novel or previously undruggable target, or for a fresh start, this program delivers a deeply characterized, data-backed hit series without locking you into a long-term engagement. You bring your protein and we deliver clarity.
Built for Progress, Not Complexity
Start with your target and assay requirements. End with a ready-to-advance hit series, complete with data, synthesized compounds, structure-function knowledge, a pharmacophore model to guide your next steps and a clear way forward.
Your program includes:
- DELabilityPro: Upfront feasibility screen to assess target tractability
- DELcore and/or DELflex: Tailored DEL screening strategies (based on FTO and goals)
- HitMiner: Proprietary AI/ML modeling and predictive prioritization
- Deep computational analysis: SAR interpretation, pharmacophore modeling, and design recommendations to guide hit progression
- Synthesis of up to 20 hit compounds
- Comprehensive final report: Structure-activity insight and progression roadmap
The Chemomics Difference, Applied Early
HitBuilder deploys the full power of X-Chem’s discovery engine: DEL design, screening, analytics, medicinal chemistry and computational science. We align our efforts to your target profile and desired outcomes. If no hits are identified, the project pauses without obligation. You can discontinue or credit work toward a future engagement; keeping your options open. Throughout the process, you’ll collaborate directly with our scientists and receive complete transparency into the data, methodology, and decision-making framework.
