X-Chem has been leading the DNA-encoded library (DEL) field for more than a decade. We have delivered over 90 programs to our partners and clients, comprising over 1,000 novel, validated hit compounds across more than 30 different target classes. Most of these projects are actively progressed by our clients and remain confidential, but examples have been published in peer-reviewed journals. We have compiled these examples into the list below: They span a wide variety of therapy areas and target classes. Some represent our older and more peptidic libraries and others exemplify more contemporary and lead-like library designs. We continue to be at the forefront of DEL development, incorporating AI in drug discovery to explore greater chemical space.
Click below to take a tour through X-Chem’s track record of success.