Build the Bridge from Hit to High-Potential Lead

LeadBuilder is designed for teams aiming to secure lead status from the start of a project. The program builds on HitBuilder, refining structure–activity relationships through iterative DMTA cycles and designing compounds that match your ideal lead profile.

This program integrates deep medicinal chemistry, predictive modeling, and collaborative strategy to deliver real progress—not just more compounds.

What You’ll Get with LeadBuilder

A fully integrated program designed to advance hits into a refined, ranked lead series. Each step combines deep medicinal chemistry, cutting-edge chemtech, intelligent modeling, and DEL-powered insight delivering real-world compounds aligned with your discovery goals.

Included in the program:

  • Strategic intake based on your target and ideal lead profile
  • DELabilityPro assessment and advancement plan
  • DELcore and/or DELflex screening (subject to FTO)
  • Structure–activity interpretation across the complete dataset
  • Iterative design, make, test, and analyze (DMTA) cycles
  • Up to 50 analogs designed, synthesized, and tested
  • Integrated computational modeling using ArtemisAI
  • Collaborative cross-functional design sessions
  • Property predictions, ADME risk flags, and design recommendations
  • Final data pack with design rationale and next-step options

What to Expect

Starting Point:

You provide the target protein and your desired lead characteristics. We tailor the approach to fit your goals.

End Point:

A refined, ranked series of lead compounds backed by design rationale, data, and documentation.

How LeadBuilder Drives Real Progress

LeadBuilder isn’t a collection of services; it’s a connected discovery engine that combines high-quality DEL data, predictive modeling, and expert chemistry into a streamlined path forward.

  • Built for programs that need clarity and confidence at the hit-to-lead stage
  • Models are trained on internal data from real campaigns, not generic public sets
  • Weekly iteration cycles ensure timely decisions and smarter analog selection
  • Seamless integration with prior work from HitBuilder and your internal data
  • Compound design driven by insight, not just enumeration
  • Medicinal chemistry informed by SAR patterns, structural data and modeling
  • Every result ties back to your target product profile and desired outcomes
  • Integrates X-Chem’s data-driven chemomics approach

Is LeadBuilder Right for You?

LeadBuilder was created for discovery teams seeking a complete, streamlined path from target to lead series. It includes everything in our HitBuilder program—plus deeper analog design, expanded synthesis, and iterative optimization. This model is likely a fit if:

  • You have a target in hand and want to move from initial hits to prioritized lead candidates
  • You’re looking for SAR insight and analog design that align with your target product profile
  • You want a structured, milestone-driven approach that integrates synthesis, modeling, and screening
  • You’re preparing for lead optimization or IND-enabling studies

Let’s Turn Potential into Progress

LeadBuilder delivers more than hit analogs. It provides a clear path forward, grounded in data, shaped by experience, and tailored to your goals. With chemistry, modeling and decision-making all connected, you get a discovery program that builds momentum and minimizes risk.

Start with confidence. Advance with purpose.