A Full-Spectrum Chemistry Partner Built for Discovery
At X-Chem, chemistry is more than a support service; it’s a strategic driver of discovery. Our integrated team of medicinal and synthetic chemists works hand-in-hand with screening, and informatics to move programs from hit to candidate with precision, speed, and scientific rigor.
We’ve been at the forefront of DEL innovation for over a decade. That experience gives us a unique advantage when interpreting screening outputs and applying them through advanced compound design, optimization, and synthesis.
Whether you’re validating hits, advancing a lead series, or designing entirely new scaffolds, we help you build the right molecule, faster.
Chemistry That Accelerates Real Progress
Integrated Design-Test Cycles
We connect chemistry, computation, and screening in a single workflow. Whether your series is DEL-derived or not, we deliver tight DMTA cycles and rapid iteration to guide decisions in real time.
Expertise Across Modalities
From CNS-penetrant scaffolds and macrocycles to degraders and covalent binders, our chemists know how to push boundaries while managing complexity. We’ve supported dozens of target classes, including GPCRs, ion channels, and nuclear receptors.
Focused on Real-World Developability
Great compounds go beyond potency. From the start, we design with PK, ADME, and safety in mind to guide chemistry toward molecules that can advance with confidence.
Transparent, Efficient Execution
You’ll get real-time visibility through our integrated ELN and LIMS systems. Every step, whether successful or not, is documented and shared. Our global synthetic chemistry team ensures consistent quality and speed at scale.
Solutions Spanning Hit to Candidate
- Hit triage and early SAR exploration
- Lead optimization and multiparameter design
- Scaffold hopping and custom synthesis
- Route scouting and scale-up (mg to gram scale)
- CNS-penetrant design (Kp,uu)
- Covalent, slow-reversible, and bispecific degrader design
- Reagent and building block development (including ReadiBLOX)
- hERG, efflux, and off-target liability reduction
- Biased GPCR / NAM / PAM ligand generation
Why Discovery Teams Choose X-Chem
Speed with Scientific Integrity
Fast DMTA doesn’t mean cutting corners. Our chemists are known for reliable execution, clear communication, and data you can trust.
Flexible Collaboration Models
From project-based requests to dedicated FTEs, we scale with you. Work directly or through platforms like Scientist.com.
Embedded in the Discovery Engine
Our chemistry team is fully integrated into X-Chem’s broader discovery platform, working in tandem with DEL screening, computational sciences, bioassays, and structure-based design. This tight connection ensures every design decision is guided by real data, every synthesis step supports the bigger strategy, and every program moves forward with clarity and purpose.
What Our Partners Say
“The favorable pricing, long-term relationship, and quality will keep us in a good position to maintain the relationship.”
“I know that your chemists in Budapest are top-notch and do an excellent job.”
“We truly appreciated working with you—your expertise, flexibility, and kindness.”
