This webinar provides practical strategies for designing and advancing beyond-Rule-of-Five (bRo5) drug candidates, with a focus on Class 3 and Class 4 compounds. Attendees will gain a deeper understanding of how to address key challenges in permeability, metabolism, and cellular uptake, which are common hurdles in this complex chemical space.

This webinar explores the use of modified in vitro assays and physicochemical design principles to better guide decision-making in early discovery. It also highlights how innovative medicinal chemistry and algorithms can be applied to improve success rates for compounds that fall outside traditional drug-like parameters.

Key Takeaways

• Understand the unique challenges and strategies for bRo5 drug design.
• Explore how in vitro assays and physicochemical properties guide bRo5 success.
• Gain insight into cutting-edge medicinal chemistry and recent innovations in this space.
• Apply practical approaches to improve uptake and reduce attrition in bRo5 programs.