DNA-encoded library (DEL) screening has historically been used to identify hits from libraries of hundreds of billions of diverse molecules. We have developed novel methods to access and leverage the DEL screens into actionable SAR. Thompson sampling is method that has been re-implemented in our hands to harvest DEL data, both positive and negative. We have also developed novel pharmacophore methods that summarize the salient features of thousands of chemically and mechanistically related DEL compounds to allow for their broader use in Med Chem design. The combined access between the two methods produces data that facilitates not just hit identification, but into datasets that facilitate rapid acceleration of Medicinal Chemistry efforts.