Enabling World-Class DEL Screening Without Starting From Scratch
DELenable isn’t just a tool. It’s the fastest path to internal DEL screening.
We give you everything you need to bring discovery in-house: ready-to-run libraries, established protocols, self-serve informatics, and expert training. You keep full control of your screening strategy. We bring the experience, the infrastructure, and the results.
DELenable powers discovery across large pharma, biotech, and academic centers without requiring your team to reinvent the wheel. Partners like Roche, AstraZeneca, and Enko now run internal screens on a proven platform, supported by the expertise that built it.
How It Works
Library Delivery
Receive ReadiDELs with access to tag-chemistry keys and sufficient aliquots for ~1,000 conditions. No synthesis required.
Screening & Sequencing
Run your own affinity or multiplexed screens using optimized X‑Chem protocols. We include full onboarding and training, from reagent QC to data analysis.
Informatics & Data Analysis
Leverage X-Chem’s informatics to enable SAR visualization, MOA clustering, and triage.
Expert Training & Support
Learn best practices for library handling, screening, analysis, and decision-making. We remain on call for consultation.
Consulting & Follow-Up
Get guidance on compound synthesis, validation, and progression to LeadBuilder or CandidateBuilder when you’re ready to advance.
Discovery Autonomy Starts Here
DELenable is ideal for teams that want to:
- Accelerate hit-finding with full internal control
- Avoid the cost and complexity of library synthesis or platform development
- Work with proteins that are difficult to transfer or stabilize externally
- Set up or scale up in-house DEL screening capability with speed and confidence
- Generate data that fuels faster synthesis, smarter optimization, and stronger leads
Proven Success with Leading Teams
Partner Testimonials
“Working together with X-Chem we were able to define a clear strategy that allowed us to build both a custom screening collection in collaboration with their synthesis group and our internal capabilities across the end-to-end DEL process. Driving both of these activities together enabled the rapid creation of a fully operational and productive DEL platform upon completion of the technology transfer collaboration.”
Enko’s fruitful and long-lasting collaboration with X-Chem has also culminated in successful technology enablement. This has empowered Enko to operate the DEL platform internally.
“Our multi-year collaboration with X-Chem has been fruitful and has resulted in projects that have successfully progressed to include many high potential products.”
DEL Discovery on Your Terms
Our chemists have supported discovery success across a wide range of modalities, targets, and partner goals.
Toolkits and Advantages:
Fully tagged DEL libraries:
Screen anywhere, with no need to build DEL synthesis capability
QC assays and tools:
Reduce risk of inconclusive or failed runs
Secure informatics portal:
Go beyond hit lists – gain insight into structure, SAR, and MOA
SOPs, documentation and training:
Ramp up quickly with proven protocols
Ongoing scientific support:
Keep learning, iterating, and evolving with X-Chem expertise
Engineered for Autonomy and Impact
DELenable gives you everything you need without the hidden costs of infrastructure, synthesis, or coding. You own the data, control your timeline, and benefit from over a decade of X-chem’s structural IP.
