Scientific Publication – X-Chem

Scientific Publication

Scientific Publication

Scientific Publication
Building Efficient Diastereo- and Enantioselective Synthetic Routes to trans-Cyclopropyl Esters for Rapid Lead Scale-Up
Cyclopropanes play an important role in drug discovery, and [...]
Scientific Publication
Multiclass Synthetic Accessibility Prediction
Evaluating synthetic accessibility of in silico molecules is an integral component [...]
Scientific Publication
Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV-2 Mpro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronavirus Homologues and Nirmatrelvir-Resistant Variants
The recent global COVID-19 pandemic has highlighted treatments for [...]
Scientific Publication
A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins
Target class-focused drug discovery has a strong track record [...]
Scientific Publication
Negishi-coupling-enabled synthesis of α-heteroaryl-α-amino acid building blocks for DNA-encoded chemical library applications
Amino acids are vital motifs in the domain of [...]
Scientific Publication
Identification, Evaluation and Optimization of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen
Bfl-1 is over-expressed in both hematological and solid tumors, [...]
Scientific Publication
Raney Nickel-Catalyzed Deuterium Labeling of Nitrogen-Containing Heterocycles and Pharmaceuticals under Continuous Flow Conditions
Deuterium-labeled compounds play a pivotal role in physical organic [...]
Scientific Publication
A General Strategy for the Amination of Electron-rich and Electron-poor Heteroaromatics by Desaturative Catalysis
The introduction of alkylamines onto heteroaromatics is integral to [...]
Scientific Publication
Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered using DNA-Encoded Chemical Library Screening
DNA-encoded chemical library (DEL) technology provides a time- and [...]
Scientific Publication
Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds
Dysregulation of IL17A drives numerous inflammatory and autoimmune disorders [...]

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