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Scientific Publication

Scientific Publication

  • Scientific Publication

    A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins

    Target class-focused drug discovery has a strong track record [...]

  • Scientific Publication

    Negishi-coupling-enabled synthesis of α-heteroaryl-α-amino acid building blocks for DNA-encoded chemical library applications

    Amino acids are vital motifs in the domain of [...]

  • Scientific Publication

    Identification, Evaluation and Optimization of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen

    Bfl-1 is over-expressed in both hematological and solid tumors, [...]

  • Scientific Publication

    Raney Nickel-Catalyzed Deuterium Labeling of Nitrogen-Containing Heterocycles and Pharmaceuticals under Continuous Flow Conditions

    Deuterium-labeled compounds play a pivotal role in physical organic [...]

  • Scientific Publication

    A General Strategy for the Amination of Electron-rich and Electron-poor Heteroaromatics by Desaturative Catalysis

    The introduction of alkylamines onto heteroaromatics is integral to [...]

  • Scientific Publication

    Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered using DNA-Encoded Chemical Library Screening

    DNA-encoded chemical library (DEL) technology provides a time- and [...]

  • Scientific Publication

    2-Aza- and 2-oxabicyclo[2.1.1]hexane derivatives as factor XIIA enzyme inhibitors

    The present invention provides compounds of formula (I): Formula [...]

  • Scientific Publication

    Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds

    Dysregulation of IL17A drives numerous inflammatory and autoimmune disorders [...]

  • Scientific Publication

    DNA-Encoded Library Technology ─ A Catalyst for Covalent Ligand Discovery

    The identification of novel covalent ligands for therapeutic purposes [...]

  • Scientific Publication

    Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen

    Evasion of apoptosis is critical for the development and [...]

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