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Scientific Publication

Scientific Publication

  • Scientific Publication

    DNA-Encoded Library Technology ─ A Catalyst for Covalent Ligand Discovery

    The identification of novel covalent ligands for therapeutic purposes [...]

  • Scientific Publication

    Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen

    Evasion of apoptosis is critical for the development and [...]

  • Scientific Publication

    Screening Ultra-Large Encoded Compound Libraries Leads to Novel Protein–Ligand Interactions and High Selectivity

    The DNA-encoded library (DEL) discovery platform has emerged as [...]

  • Scientific Publication

    Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning

    WD40 repeat-containing protein 91 (WDR91) regulates early-to-late endosome conversion [...]

  • Scientific Publication

    Discovery of Nanomolar DCAF1 Small Molecule Ligands

    DCAF1 is a substrate receptor of two distinct E3 [...]

  • Scientific Publication

    Discovery of a selective c-MET inhibitor with a novel binding mode

    The c-MET receptor tyrosine kinase has received considerable attention [...]

  • Scientific Publication

    The expanding reaction toolkit for DNA-encoded libraries

    Over the past decade, DNA-encoded libraries (DELs) have emerged [...]

  • Scientific Publication

    Discovery of Novel UDP-N-Acetylglucosamine Acyltransferase (LpxA) Inhibitors with Activity against Pseudomonas aeruginosa

    This study describes a novel series of UDP-N-acetylglucosamine acyltransferase [...]

  • Scientific Publication

    Novel irreversible covalent BTK inhibitors discovered using DNA-encoded chemistry

    Libraries of DNA-Encoded small molecules created using combinatorial chemistry [...]

  • Scientific Publication

    Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening

    Inhibition of hydroxy acid oxidase 1 (HAO1) is a [...]

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