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Scientific Publication

Scientific Publication

  • Scientific Publication

    A General Strategy for the Amination of Electron-rich and Electron-poor Heteroaromatics by Desaturative Catalysis

    The introduction of alkylamines onto heteroaromatics is integral to [...]

  • Scientific Publication

    Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered using DNA-Encoded Chemical Library Screening

    DNA-encoded chemical library (DEL) technology provides a time- and [...]

  • Scientific Publication

    Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds

    Dysregulation of IL17A drives numerous inflammatory and autoimmune disorders [...]

  • Scientific Publication

    DNA-Encoded Library Technology ─ A Catalyst for Covalent Ligand Discovery

    The identification of novel covalent ligands for therapeutic purposes [...]

  • Scientific Publication

    Structural Investigations on Macrocycles Originating from a DNA-Encoded Chemical Library Screen

    Evasion of apoptosis is critical for the development and [...]

  • Scientific Publication

    Screening Ultra-Large Encoded Compound Libraries Leads to Novel Protein–Ligand Interactions and High Selectivity

    The DNA-encoded library (DEL) discovery platform has emerged as [...]

  • Scientific Publication

    Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning

    WD40 repeat-containing protein 91 (WDR91) regulates early-to-late endosome conversion [...]

  • Scientific Publication

    Discovery of Nanomolar DCAF1 Small Molecule Ligands

    DCAF1 is a substrate receptor of two distinct E3 [...]

  • Scientific Publication

    Discovery of a selective c-MET inhibitor with a novel binding mode

    The c-MET receptor tyrosine kinase has received considerable attention [...]

  • Scientific Publication

    The expanding reaction toolkit for DNA-encoded libraries

    Over the past decade, DNA-encoded libraries (DELs) have emerged [...]

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      • GPCR Discovery
    • DEL Track Record
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