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    Structural insight into allosteric modulation of protease-activated receptor 2

    Structural insight into allosteric modulation of protease-activated receptor 2 [...]

  • Scientific Publication

    Pharmacological property optimization for allosteric ligands: A medicinal chemistry perspective.

    New strategies to potentially improve drug safety and efficacy [...]

  • Scientific Publication

    Agonists and Antagonists of Protease-Activated Receptor 2 Discovered within a DNA-Encoded Chemical Library Using Mutational Stabilization of the Target

    January 9, 2018 | Sage Journals | Agonists and [...]

  • Scientific Publication

    Discovery of a potent BTK inhibitor with a novel binding mode using parallel selections with a DNA-encoded chemical library.

    Discovery of a potent BTK inhibitor with a novel [...]

  • Scientific Publication

    Structure Based Design of Non-Natural Peptidic Macrocyclic Mcl-1 Inhibitors

    Mcl-1 is a pro-apoptotic BH3 protein family member similar [...]

  • Scientific Publication

    DNA-encoded chemistry: enabling the deeper sampling of chemical space.

    Publication: Nat Rev Drug Discov. DNA-encoded chemical library technologies are [...]

  • Scientific Publication

    Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using DNA-encoded library technology.

    Discovery of cofactor-specific, bactericidal Mycobacterium tuberculosis InhA inhibitors using [...]

  • Scientific Publication

    Bromodomain inhibitors regulate the C9ORF72 locus in ALS

    A hexanucleotide repeat expansion residing within the C9ORF72 gene [...]

  • Scientific Publication

    Targets and Emerging Therapies for Schizophrenia

    New and emerging directions in pharmaceutical research to better [...]

  • Scientific Publication

    Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library.

    Encoded Library Synthesis Using Chemical Ligation and the Discovery [...]

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