May 27, 2019

Novel Nucleic Acid Binding Small Molecules Discovered Using DNA-Encoded Chemistry.

May 27, 2019|Molecules|Novel Nucleic Acid Binding Small Molecules Discovered Using DNA-Encoded Chemistry

Inspired by the many reported successful applications of DNA-encoded chemical libraries in drug discovery projects with protein targets, we decided to apply this platform to nucleic acid targets. We used a 120-billion-compound set of 33 distinct DNA-encoded chemical libraries and affinity-mediated selection to discover binders to a panel of DNA targets.

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