X‑Chem and the SGC are pioneering crowd-sourced AI advancements by making DEL screening data public. 

February 21, 2024

Artificial intelligence (AI) is now recognized as an indispensable component of the modern drug discovery tool kit, applied at all...


Unlocking Chemical Space: The Power of DEL Screening 

January 29, 2024

Most readers will be familiar with the parable of the “search”, in which a drunk person searches for their lost...


Success Stories of DEL Enablement

November 15, 2023

X-Chem’s primary mission has always been to leverage the world’s leading drug discovery platform to help create molecules that will...


Proximity Labeling: DEL Selection Without Capturing the Target

October 18, 2023

DNA-encoded library (DEL) selections typically use affinity pulldown to enrich compounds that bind targets of interest. While it is highly...


The Power of DNA-Encoded Libraries for Covalent Inhibitor Discovery

September 13, 2023

Most of the pharmaceutical industry’s reported drug discovery projects involve reversible target modulators. However, covalent inhibitors — i.e., irreversible —...


DEL Screen Artifacts: How to Find and Avoid Them

August 16, 2023

As experts in the DNA-encoded chemical library (DEL) field with over twelve years of experience in screening DELs, X-Chem has...


DEL Technology and Targeted Protein Degradation Discovery

July 19, 2023

Targeted protein degradation (TPD) is a rapidly growing field that aims to selectively eliminate disease-causing proteins.1,2 Proteolysis targeting chimeras (PTCs)...


Protein-Protein Interactions: A Key to Precision Medicine

June 21, 2023

Protein-protein interactions (PPIs) are the foundation of life, controlling everything from cell growth and division to metabolism and signaling.1 Targeting...


Going Beyond Hit ID With Machine Learning & Del: The Prediction of Building Block Reactivity

June 7, 2023

Since X-Chem and Google’s seminal collaboration applying machine learning (ML) to DNA-encoded chemical library (DEL) screening output, ML has taken...


Through the Lens of a Lead Discovery Scientist: Enabling Hit Identification Through DNA-Encoded Libraries

February 15, 2023

The phrase “you miss 100% of the shots you don’t take” was originally coined by Wayne Gretzky about scoring goals...