Blog

Driving Discovery Through Miniaturized High-Throughput Chemistry

May 28, 2024

When chemists approach the formation of a new bond, they often choose reaction conditions that they (or their colleagues) are...

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Refining covalent warhead reactivity: A new look at GSH reactivity assays

April 29, 2024

If the bond is forever, it needs to be safe.   Covalent drugs have proved to be successful therapies for various...

Blog

Log KIAM Is the New LogD

March 29, 2024

By Johan Bartholomeus, Senior Principal Scientist, and Philippe McGee, Principal Scientist  In a drug discovery project, during the hit-to-lead and...

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X‑Chem and the SGC are pioneering crowd-sourced AI advancements by making DEL screening data public 

February 21, 2024

Artificial intelligence (AI) is now recognized as an indispensable component of the modern drug discovery tool kit, applied at all...

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Unlocking Chemical Space: The Power of DEL Screening 

January 29, 2024

Most readers will be familiar with the parable of the “search”, in which a drunk person searches for their lost...

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Success Stories of DEL Enablement

November 15, 2023

X-Chem’s primary mission has always been to leverage the world’s leading drug discovery platform to help create molecules that will...

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Proximity Labeling: DEL Selection Without Capturing the Target

October 18, 2023

DNA-encoded library (DEL) selections typically use affinity pulldown to enrich compounds that bind targets of interest. While it is highly...

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The Power of DNA-Encoded Libraries for Covalent Inhibitor Discovery

September 13, 2023

Most of the pharmaceutical industry’s reported drug discovery projects involve reversible target modulators. However, covalent inhibitors — i.e., irreversible —...

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DEL Screen Artifacts: How to Find and Avoid Them

August 16, 2023

As experts in the DNA-encoded chemical library (DEL) field with over twelve years of experience in screening DELs, X-Chem has...

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DEL Technology and Targeted Protein Degradation Discovery

July 19, 2023

Targeted protein degradation (TPD) is a rapidly growing field that aims to selectively eliminate disease-causing proteins.1,2 Proteolysis targeting chimeras (PTCs)...