Flow Chemistry for Contemporary Isotope Labeling
Isotope-labeled compounds have emerged as important tools in drug discovery and development. The incorporated isotopes, particularly deuterium, in pharmaceuticals, have...
Driving Discovery Through Miniaturized High-Throughput Chemistry
When chemists approach the formation of a new bond, they often choose reaction conditions that they (or their colleagues) are...
Refining covalent warhead reactivity: A new look at GSH reactivity assays
If the bond is forever, it needs to be safe. Covalent drugs have proved to be successful therapies for various...
Log KIAM Is the New LogD
By Johan Bartholomeus, Senior Principal Scientist, and Philippe McGee, Principal Scientist In a drug discovery project, during the hit-to-lead and...
X‑Chem and the SGC are pioneering crowd-sourced AI advancements by making DEL screening data public
Artificial intelligence (AI) is now recognized as an indispensable component of the modern drug discovery tool kit, applied at all...
Unlocking Chemical Space: The Power of DEL Screening
Most readers will be familiar with the parable of the “search”, in which a drunk person searches for their lost...
Success Stories of DEL Enablement
X-Chem’s primary mission has always been to leverage the world’s leading drug discovery platform to help create molecules that will...
Proximity Labeling: DEL Selection Without Capturing the Target
DNA-encoded library (DEL) selections typically use affinity pulldown to enrich compounds that bind targets of interest. While it is highly...
The Power of DNA-Encoded Libraries for Covalent Inhibitor Discovery
Most of the pharmaceutical industry’s reported drug discovery projects involve reversible target modulators. However, covalent inhibitors — i.e., irreversible —...
DEL Screen Artifacts: How to Find and Avoid Them
As experts in the DNA-encoded chemical library (DEL) field with over twelve years of experience in screening DELs, X-Chem has...