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X‑Chem’s DNA-Encoded Library (DEL) Platform Enables the Discovery of Lead-Like Molecules for Medicinal Chemistry Progression

November 10, 2021

Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening X-Chem’s DNA-encoded library (DEL)...

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Mechanistic Understanding of a Difficult GPCR Aided by DEL and Medicinal Chemistry

October 18, 2021

Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition GPCRs are important targets to investigate, not just for...

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Beyond DNA-Encoded Library Screening: How Integrated Services Improve the Outcome of the Drug Discovery Program

September 14, 2021

As the industry leader in DNA-encoded library (DEL) technology, X-Chem’s core business has been the hunt for novel small molecule...

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Focusing on building blocks and properties is the best way to design better DNA-Encoded Libraries (DELs)

August 3, 2021

It seems to be a common experience. Your new drug discovery project has accessed a DEL screen and you’re eagerly...

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Applying DNA-Encoded Chemistry to the Discovery of Irreversible Covalent Inhibitors

July 15, 2021

Some of the most commonly used drugs elicit their therapeutic effects by forming covalent bonds with their targets; examples include...

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Proof of Concept: DEL for PROTACs

June 15, 2021

DNA-Encoded Chemical Library Screening Is a Great Tool for Identifying Novel Binders Suitable for Bispecific Degraders The Value of DEL...

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Truncations, Side Products and Truth in Labeling for DNA-Encoded Libraries: A Cautionary Tale

May 11, 2021

Did you ever search a library catalog, dutifully note the location of a book that is allegedly not checked out,...