Blog

The Power of DNA-Encoded Libraries for Covalent Inhibitor Discovery

September 13, 2023

Most of the pharmaceutical industry’s reported drug discovery projects involve reversible target modulators. However, covalent inhibitors — i.e., irreversible —...

Blog

DEL Screen Artifacts: How to Find and Avoid Them

August 16, 2023

As experts in the DNA-encoded chemical library (DEL) field with over twelve years of experience in screening DELs, X-Chem has...

Blog

DEL Technology and Targeted Protein Degradation Discovery

July 19, 2023

Targeted protein degradation (TPD) is a rapidly growing field that aims to selectively eliminate disease-causing proteins.1,2 Proteolysis targeting chimeras (PTCs)...

Blog

Protein-Protein Interactions: A Key to Precision Medicine

June 21, 2023

Protein-protein interactions (PPIs) are the foundation of life, controlling everything from cell growth and division to metabolism and signaling.1 Targeting...

Blog

Going Beyond Hit ID With Machine Learning & Del: The Prediction of Building Block Reactivity

June 7, 2023

Since X-Chem and Google’s seminal collaboration applying machine learning (ML) to DNA-encoded chemical library (DEL) screening output, ML has taken...

Blog

Through the Lens of a Lead Discovery Scientist: Enabling Hit Identification Through DNA-Encoded Libraries

February 15, 2023

The phrase “you miss 100% of the shots you don’t take” was originally coined by Wayne Gretzky about scoring goals...

Blog

A Year of Driving Small Molecule Discovery

January 3, 2023

2022 was a big year here at X-Chem, so as we embark into 2023 it seems like a good time...

Blog

The 10th International Symposium on DNA-Encoded Chemical Libraries

November 30, 2022

Earlier this month I had the pleasure of attending the 10th International Symposium on DNA-Encoded Chemical Libraries (informally referred to...

Blog

New Directions in DEL Research

October 24, 2022

At X-Chem, we make it a priority to stay engaged with the latest advances in DNA-encoded library (DEL) technology and...

Blog

Solution DEL and Bead DEL: Two Tools for Advancing Drug Discovery

September 13, 2022

In 1992, the late professors Brenner and Lerner were the first to publish the concept of encoding synthetic chemistry with...