DELability – Protein Assessment for DEL Screening

July 20, 2022

Over the last 5 years, biopharma has fully embraced the use of DNA-encoded libraries (DELs) for hit identification for all...


Does Size Matter in DEL Screening?

June 23, 2022

One of the most attractive aspects of DNA-encoded library (DEL) technology is the vast number of compounds that can be...


X‑Chem’s New ReadiDELs Offer a Shorter Route to the Benefits of DEL Innovation

May 6, 2022

The last two years have seen X-Chem transform itself from a boutique DEL screening shop to an integrated drug discovery...


Getting Back to In Person

April 13, 2022

I recently had the pleasure of taking a trip to the West Coast to meet with several X-Chem clients. They...


A Track Record of Success

March 15, 2022

For those who didn’t notice, X-Chem underwent a major rebranding in mid-2021. We rolled out our new website, logo, color...


Where AI Is Heading and Why X‑Chem Is Positioned to Lead

February 15, 2022

The use of AI to increase the efficiency of drug discovery has increased considerably over the past few years. Drug...


Software and Science Go Hand in Hand at X‑Chem: Informatics Tools for a Scalable and Effective DEL Platform

January 13, 2022

From the very beginnings of X-Chem, we recognized the need to invest in software capabilities. DNA-encoded library (DEL) technology generates...


What a Year! X‑Chem 2021 in Review

December 7, 2021

The month of December is often a time to take stock and assess the accomplishments of the past year. As...


X‑Chem’s DNA-Encoded Library (DEL) Platform Enables the Discovery of Lead-Like Molecules for Medicinal Chemistry Progression

November 10, 2021

Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening X-Chem’s DNA-encoded library (DEL)...


Mechanistic Understanding of a Difficult GPCR Aided by DEL and Medicinal Chemistry

October 18, 2021

Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition GPCRs are important targets to investigate, not just for...