DEL Technology and Targeted Protein Degradation Discovery

July 19, 2023

Targeted protein degradation (TPD) is a rapidly growing field that aims to selectively eliminate disease-causing proteins.1,2 Proteolysis targeting chimeras (PTCs)...


Protein-Protein Interactions: A Key to Precision Medicine

June 21, 2023

Protein-protein interactions (PPIs) are the foundation of life, controlling everything from cell growth and division to metabolism and signaling.1 Targeting...


Going Beyond Hit ID With Machine Learning & Del: The Prediction of Building Block Reactivity

June 7, 2023

Since X-Chem and Google’s seminal collaboration applying machine learning (ML) to DNA-encoded chemical library (DEL) screening output, ML has taken...


Through the Lens of a Lead Discovery Scientist: Enabling Hit Identification Through DNA-Encoded Libraries

February 15, 2023

The phrase “you miss 100% of the shots you don’t take” was originally coined by Wayne Gretzky about scoring goals...


A Year of Driving Small Molecule Discovery

January 3, 2023

2022 was a big year here at X-Chem, so as we embark into 2023 it seems like a good time...


The 10th International Symposium on DNA-Encoded Chemical Libraries

November 30, 2022

Earlier this month I had the pleasure of attending the 10th International Symposium on DNA-Encoded Chemical Libraries (informally referred to...


New Directions in DEL Research

October 24, 2022

At X-Chem, we make it a priority to stay engaged with the latest advances in DNA-encoded library (DEL) technology and...


Solution DEL and Bead DEL: Two Tools for Advancing Drug Discovery

September 13, 2022

In 1992, the late professors Brenner and Lerner were the first to publish the concept of encoding synthetic chemistry with...


DELability – Protein Assessment for DEL Screening

July 20, 2022

Over the last 5 years, biopharma has fully embraced the use of DNA-encoded libraries (DELs) for hit identification for all...


Does Size Matter in DEL Screening?

June 23, 2022

One of the most attractive aspects of DNA-encoded library (DEL) technology is the vast number of compounds that can be...