Where AI Is Heading and Why X‑Chem Is Positioned to Lead

February 15, 2022

The use of AI to increase the efficiency of drug discovery has increased considerably over the past few years. Drug...


Software and Science Go Hand in Hand at X‑Chem: Informatics Tools for a Scalable and Effective DEL Platform

January 13, 2022

From the very beginnings of X-Chem, we recognized the need to invest in software capabilities. DNA-encoded library (DEL) technology generates...


What a Year! X‑Chem 2021 in Review

December 7, 2021

The month of December is often a time to take stock and assess the accomplishments of the past year. As...


X‑Chem’s DNA-Encoded Library (DEL) Platform Enables the Discovery of Lead-Like Molecules for Medicinal Chemistry Progression

November 10, 2021

Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening X-Chem’s DNA-encoded library (DEL)...


Mechanistic Understanding of a Difficult GPCR Aided by DEL and Medicinal Chemistry

October 18, 2021

Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition GPCRs are important targets to investigate, not just for...


Focusing on building blocks and properties is the best way to design better DNA-Encoded Libraries (DELs)

August 3, 2021

It seems to be a common experience. Your new drug discovery project has accessed a DEL screen and you’re eagerly...


Applying DNA-Encoded Chemistry to the Discovery of Irreversible Covalent Inhibitors

July 15, 2021

Some of the most commonly used drugs elicit their therapeutic effects by forming covalent bonds with their targets; examples include...


Proof of Concept: DEL for PROTACs

June 15, 2021

DNA-Encoded Chemical Library Screening Is a Great Tool for Identifying Novel Binders Suitable for Bispecific Degraders The Value of DEL...


Truncations, Side Products and Truth in Labeling for DNA-Encoded Libraries: A Cautionary Tale

May 11, 2021

Did you ever search a library catalog, dutifully note the location of a book that is allegedly not checked out,...