Scientific Publication

Building Efficient Diastereo- and Enantioselective Synthetic Routes to trans-Cyclopropyl Esters for Rapid Lead Scale-Up

March 13, 2025

Scientific Publication

Multiclass Synthetic Accessibility Prediction

January 22, 2025

Scientific Publication

Rational Design of Macrocyclic Noncovalent Inhibitors of SARS-CoV-2 Mpro from a DNA-Encoded Chemical Library Screening Hit That Demonstrate Potent Inhibition against Pan-Coronavirus Homologues and Nirmatrelvir-Resistant Variants

December 11, 2024

Scientific Publication

A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins

November 7, 2024

Scientific Publication

Negishi-coupling-enabled synthesis of α-heteroaryl-α-amino acid building blocks for DNA-encoded chemical library applications

August 12, 2024

Scientific Publication

Identification, Evaluation and Optimization of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen

May 20, 2024

Scientific Publication

Raney Nickel-Catalyzed Deuterium Labeling of Nitrogen-Containing Heterocycles and Pharmaceuticals under Continuous Flow Conditions

May 14, 2024

Scientific Publication

A General Strategy for the Amination of Electron-rich and Electron-poor Heteroaromatics by Desaturative Catalysis

April 24, 2024

Scientific Publication

Inhibitors of the Thioesterase Activity of Mycobacterium tuberculosis Pks13 Discovered using DNA-Encoded Chemical Library Screening 

April 5, 2024

Scientific Publication

Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds 

April 4, 2024