GPCR Modulators and Screening Optimization for New Chemotypes Using DNA-Encoded Libraries
In this webinar, Dr. Anthony Keefe and Dr. Johan Bartholomeus will discuss components of GPCR modulator optimization including affinity, efficacy, signal bias and kinetics. As understanding of GPCR pharmacology has increased, so have methods to screen for them. The featured speakers will also describe robust methods that have been developed using DNA-encoded library (DEL) technology to screen libraries of >100 billion compounds to identify high-quality, drug-like hits that are completely structurally novel even among hits for GPCR targets that have undergone extensive screening through other technologies.
Key Takeaways:
- See the key principles involved in the discovery and optimization of GPCR modulators
- Understand the use of DEL screening methods to find high-quality and structurally diverse novel hits as starting points in the development of new GPCR modulators
Presented by:
Dr. Johan Bartholomeus
Senior Principal Scientist
Anthony Keefe, Ph.D.
Senior Vice President, Innovation