Mitokinin, Inc., USA .; Preparation of purinamines and pyrrolopyrimidinamines, compositions and methods of using the same for treatment of neurodegenerative and mitochondrial disease
The present disclosure is directed to nitrogen-containing heteroaryl analogs, methods of making nitrogen-containing analogs, and methods of treating disorders associated with PINK1 kinase activity including, but not limited to, neurodegenerative diseases, mitochondrial diseases, fibrosis, and/or cardiomyopathy using these analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.