What a Year! X‑Chem 2021 in Review
The month of December is often a time to take stock and assess the accomplishments of the past year. As...
X‑Chem’s DNA-Encoded Library (DEL) Platform Enables the Discovery of Lead-Like Molecules for Medicinal Chemistry Progression
Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening X-Chem’s DNA-encoded library (DEL)...
Mechanistic Understanding of a Difficult GPCR Aided by DEL and Medicinal Chemistry
Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition GPCRs are important targets to investigate, not just for...
Focusing on building blocks and properties is the best way to design better DNA-Encoded Libraries (DELs)
It seems to be a common experience. Your new drug discovery project has accessed a DEL screen and you’re eagerly...
Applying DNA-Encoded Chemistry to the Discovery of Irreversible Covalent Inhibitors
Some of the most commonly used drugs elicit their therapeutic effects by forming covalent bonds with their targets; examples include...
Proof of Concept: DEL for PROTACs
DNA-Encoded Chemical Library Screening Is a Great Tool for Identifying Novel Binders Suitable for Bispecific Degraders The Value of DEL...
Truncations, Side Products and Truth in Labeling for DNA-Encoded Libraries: A Cautionary Tale
Did you ever search a library catalog, dutifully note the location of a book that is allegedly not checked out,...