What a Year! X‑Chem 2021 in Review
The month of December is often a time to take stock and assess the accomplishments of the past year. As...
X‑Chem’s DNA-Encoded Library (DEL) Platform Enables the Discovery of Lead-Like Molecules for Medicinal Chemistry Progression
Discovery of Novel, Potent Inhibitors of Hydroxy Acid Oxidase 1 (HAO1) Using DNA-Encoded Chemical Library Screening X-Chem’s DNA-encoded library (DEL)...
Mechanistic Understanding of a Difficult GPCR Aided by DEL and Medicinal Chemistry
Protease-activated receptor-2 ligands reveal orthosteric and allosteric mechanisms of receptor inhibition GPCRs are important targets to investigate, not just for...
Beyond DNA-Encoded Library Screening: How Integrated Services Improve the Outcome of the Drug Discovery Program
As the industry leader in DNA-encoded library (DEL) technology, X-Chem’s core business has been the hunt for novel small molecule...
Focusing on building blocks and properties is the best way to design better DNA-Encoded Libraries (DELs)
It seems to be a common experience. Your new drug discovery project has accessed a DEL screen and you’re eagerly...
Applying DNA-Encoded Chemistry to the Discovery of Irreversible Covalent Inhibitors
Some of the most commonly used drugs elicit their therapeutic effects by forming covalent bonds with their targets; examples include...
Proof of Concept: DEL for PROTACs
DNA-Encoded Chemical Library Screening Is a Great Tool for Identifying Novel Binders Suitable for Bispecific Degraders The Value of DEL...
Truncations, Side Products and Truth in Labeling for DNA-Encoded Libraries: A Cautionary Tale
Did you ever search a library catalog, dutifully note the location of a book that is allegedly not checked out,...